Mutation of a critical arginine in the GTP-binding site of transglutaminase 2 disinhibits intracellular cross-linking activity
GE Begg, SR Holman, PH Stokes, JM Matthews… - Journal of Biological …, 2006 - ASBMB
Transglutaminase type 2 (TG2; also known as G h) is a multifunctional protein involved in
diverse cellular processes. It has two well characterized enzyme activities: receptor-
stimulated signaling that requires GTP binding and calcium-activated transamidation or
cross-linking that is inhibited by GTP. In addition to the GDP binding residues identified from
the human TG2 crystal structure (Liu, S., Cerione, RA, and Clardy, J.(2002) Proc. Natl. Acad.
Sci. USA 99, 2743-2747), we have previously implicated Ser 171 in GTP binding, as binding …
diverse cellular processes. It has two well characterized enzyme activities: receptor-
stimulated signaling that requires GTP binding and calcium-activated transamidation or
cross-linking that is inhibited by GTP. In addition to the GDP binding residues identified from
the human TG2 crystal structure (Liu, S., Cerione, RA, and Clardy, J.(2002) Proc. Natl. Acad.
Sci. USA 99, 2743-2747), we have previously implicated Ser 171 in GTP binding, as binding …
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