Mutations in BHD and TP53 genes, but not in HNF1β gene, in a large series of sporadic chromophobe renal cell carcinoma
S Gad, SH Lefevre, SK Khoo, S Giraud… - British journal of …, 2007 - nature.com
British journal of cancer, 2007•nature.com
Abstract BHD, TP53, and HNF1β on chromosome 17 were studied in 92 cases of renal cell
carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen,
and zero cases had, respectively BHD, TP53, and HNF1β mutations,(84% mutations
involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype.
carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen,
and zero cases had, respectively BHD, TP53, and HNF1β mutations,(84% mutations
involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype.
Abstract
BHD, TP53, and HNF1β on chromosome 17 were studied in 92 cases of renal cell carcinoma (46 chromophobe, 19 clear cell, 18 oncocytoma, and nine papillary). Six, thirteen, and zero cases had, respectively BHD, TP53, and HNF1β mutations,(84% mutations involved chromophobe), suggesting a role for BHD and TP53 in chromophobe subtype.
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