Mycobacterium avium enters a state of metabolic dormancy in response to starvation
RJ Archuleta, PY Hoppes, TP Primm - Tuberculosis, 2005 - Elsevier
Members of the Mycobacterium avium complex (MAC) exhibit a highly effective and biphasic
response to starvation, losing less than 90% viability after 2 years in deionized water. During
the first adaptive phase of 4–7 days, the bacilli exhibit a burst of lipid catabolism, alteration of
mycolate modifications, loss of catalase and urease activities, and a decline in sensitivity to
antibiotics. There is also a decline in the protein level of alanine tRNA synthetase (AlaS),
and an increase in ribonuclease E (Rne) levels. During the following persistence phase, the …
response to starvation, losing less than 90% viability after 2 years in deionized water. During
the first adaptive phase of 4–7 days, the bacilli exhibit a burst of lipid catabolism, alteration of
mycolate modifications, loss of catalase and urease activities, and a decline in sensitivity to
antibiotics. There is also a decline in the protein level of alanine tRNA synthetase (AlaS),
and an increase in ribonuclease E (Rne) levels. During the following persistence phase, the …