Tuberculosis remains a major health concern worldwide. Eradication of its causative agent,
the bacterial pathogen Mycobacterium tuberculosis, is particularly challenging due to a vast
reservoir of latent carriers of the disease. Despite the misleading terminology of a so-called
dormant state associated with latent infections, the bacteria have to maintain basic metabolic
activities. Hypoxic conditions have been widely used as an in vitro system to study this
dormancy. Such studies identified a rearrangement of central carbon metabolism to exploit …