Myonuclear accretion is a determinant of exercise-induced remodeling in skeletal muscle
Skeletal muscle adapts to external stimuli such as increased work. Muscle progenitors (MPs)
control muscle repair due to severe damage, but the role of MP fusion and associated
myonuclear accretion during exercise are unclear. While we previously demonstrated that
MP fusion is required for growth using a supra-physiological model (Goh and Millay, 2017),
questions remained about the need for myonuclear accrual during muscle adaptation in a
physiological setting. Here, we developed an 8 week high-intensity interval training (HIIT) …
control muscle repair due to severe damage, but the role of MP fusion and associated
myonuclear accretion during exercise are unclear. While we previously demonstrated that
MP fusion is required for growth using a supra-physiological model (Goh and Millay, 2017),
questions remained about the need for myonuclear accrual during muscle adaptation in a
physiological setting. Here, we developed an 8 week high-intensity interval training (HIIT) …
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