Background N-acetylcysteine (NAC) has been shown to potentiate the effects of nitroglycerin
(NTG) and to have antioxidant activity. This is the first study to assess the safety and effect of
NAC in the treatment of evolving acute myocardial infarction (AMI). Methods and Results
Patients with AMI received either 15 g NAC infused over 24 hours (n= 20) or no NAC (n= 7),
combined with intravenous NTG and streptokinase. Peripheral venous plasma
malondialdehyde (MDA), reduced (GSH) and oxidized (GSSG) glutathione concentrations …

… N-acetylcysteine in combination with nitroglycerin and streptokinase for the treatment of
evolving acute myocardial infarction: safety and biochemical effects. … N-acetylcysteine
attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart
failure. … Use of N-acetylcysteine in the management of coronary artery diseases. …