N-terminal EFRH sequence of Alzheimer's β-amyloid peptide represents the epitope of its anti-aggregating antibodies
D Frenkel, M Balass, B Solomon - Journal of neuroimmunology, 1998 - Elsevier
Monoclonal antibodies 6C6 and 10D5 raised against the N-terminal of β-amyloid peptide
interfere with the formation of β-amyloid and trigger reversal to its non-toxic components.
The epitopes of these antibodies were localized employing a library composed of
filamentous phage displaying random combinatorial hexapeptides. Among 44 positive
phage-clones, selected from the library by both antibodies, 40 clones carried the consensus
sequence EFRH. These EFRH phage-clones bind specifically mAbs 6C6 or 10D5 with an …
interfere with the formation of β-amyloid and trigger reversal to its non-toxic components.
The epitopes of these antibodies were localized employing a library composed of
filamentous phage displaying random combinatorial hexapeptides. Among 44 positive
phage-clones, selected from the library by both antibodies, 40 clones carried the consensus
sequence EFRH. These EFRH phage-clones bind specifically mAbs 6C6 or 10D5 with an …
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