NADPH oxidase 2 interaction with TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression
Gp91 phox/NADPH oxidase (NOX) 2 is the main catalytic component of NOX, which
mediates the phagocytic killing of ingested pathogens via the production of reactive oxygen
species (ROS). However, Mycobacterium tuberculosis (Mtb) is relatively resistant to the
microbicidal effects of ROS. Thus, the exact roles of NOX2 in the innate immune control
against Mtb infection are not fully resolved. In this study, we show that NOX2 is essential for
TLR2-dependent inflammatory responses and 1, 25-dihydroxyvitamin D 3 (1, 25D 3) …
mediates the phagocytic killing of ingested pathogens via the production of reactive oxygen
species (ROS). However, Mycobacterium tuberculosis (Mtb) is relatively resistant to the
microbicidal effects of ROS. Thus, the exact roles of NOX2 in the innate immune control
against Mtb infection are not fully resolved. In this study, we show that NOX2 is essential for
TLR2-dependent inflammatory responses and 1, 25-dihydroxyvitamin D 3 (1, 25D 3) …
[引用][C] NADPH oxidase 2 interaction wide TLR2 is required for efficient innate immune responses to mycobacteria via cathelicidin expression
Y CS - J Immunol, 2009 - cir.nii.ac.jp
NADPH oxidase 2 interaction wide TLR2 is required for efficient innate immune responses
to mycobacteria via cathelicidin expression | CiNii Research … NADPH oxidase 2
interaction wide TLR2 is required for efficient innate immune responses to mycobacteria via
cathelicidin expression …
to mycobacteria via cathelicidin expression | CiNii Research … NADPH oxidase 2
interaction wide TLR2 is required for efficient innate immune responses to mycobacteria via
cathelicidin expression …
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