NK Cell–Specific CDK8 deletion enhances antitumor responses
A Witalisz-Siepracka, D Gotthardt… - Cancer immunology …, 2018 - AACR
Abstract Cyclin-dependent kinase 8 (CDK8) is a member of the transcription-regulating CDK
family. CDK8 activates or represses transcription by associating with the mediator complex
or by regulating transcription factors. Oncogenic activity of CDK8 has been demonstrated in
several cancer types. Targeting CDK8 represents a potential therapeutic strategy. Because
knockdown of CDK8 in a natural killer (NK) cell line enhances cytotoxicity and NK cells
provide the first line of immune defense against transformed cells, we asked whether …
family. CDK8 activates or represses transcription by associating with the mediator complex
or by regulating transcription factors. Oncogenic activity of CDK8 has been demonstrated in
several cancer types. Targeting CDK8 represents a potential therapeutic strategy. Because
knockdown of CDK8 in a natural killer (NK) cell line enhances cytotoxicity and NK cells
provide the first line of immune defense against transformed cells, we asked whether …
[引用][C] NK cell-specific CDK8 deletion enhances antitumor responses. Cancer Immunol. Res. 2018; 6: 458–466. doi: 10.1158/2326-6066
A Witalisz-Siepracka, D Gotthardt, M Prchal-Murphy… - CIR-17-0183.[Abstract][CrossRef] …
以上显示的是最相近的搜索结果。 查看全部搜索结果