NPY neuron-specific Y2 receptors regulate adipose tissue and trabecular bone but not cortical bone homeostasis in mice
YC Shi, S Lin, IPL Wong, PA Baldock, A Aljanova… - PloS one, 2010 - journals.plos.org
Background Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-
mediated effects on energy homeostasis and bone physiology. Y2 receptors are located
post-synaptically as well as acting as auto receptors on NPY-expressing neurons, and the
different roles of these two populations of Y2 receptors in the regulation of energy
homeostasis and body composition are unclear. Methodology/Principal Findings We thus
generated two conditional knockout mouse models, Y2lox/lox and NPYCre/+; Y2lox/lox, in …
mediated effects on energy homeostasis and bone physiology. Y2 receptors are located
post-synaptically as well as acting as auto receptors on NPY-expressing neurons, and the
different roles of these two populations of Y2 receptors in the regulation of energy
homeostasis and body composition are unclear. Methodology/Principal Findings We thus
generated two conditional knockout mouse models, Y2lox/lox and NPYCre/+; Y2lox/lox, in …
[PDF][PDF] NPY Neuron-Specific Y2 Receptors Regulate Adipose Tissue and Trabecular Bone but Not
YC Shi, S Lin, IPL Wong, PA Baldock, A Aljanova - 2010 - academia.edu
Background: Y2 receptor signalling is known to be important in neuropeptide Y (NPY)-
mediated effects on energy homeostasis and bone physiology. Y2 receptors are located
post-synaptically as well as acting as auto receptors on NPY-expressing neurons, and the
different roles of these two populations of Y2 receptors in the regulation of energy
homeostasis and body composition are unclear. Methodology/Principal Findings: We thus
generated two conditional knockout mouse models, Y2lox/lox and NPYCre/+; Y2 lox/lox, in …
mediated effects on energy homeostasis and bone physiology. Y2 receptors are located
post-synaptically as well as acting as auto receptors on NPY-expressing neurons, and the
different roles of these two populations of Y2 receptors in the regulation of energy
homeostasis and body composition are unclear. Methodology/Principal Findings: We thus
generated two conditional knockout mouse models, Y2lox/lox and NPYCre/+; Y2 lox/lox, in …
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