Nanoparticles as synthetic vaccines

JD Smith, LD Morton, BD Ulery - Current opinion in biotechnology, 2015 - Elsevier
nanoparticle-based vaccine delivery, biomolecular materials possess many positive attributes
which make them exciting candidates for use in synthetic vaccine … as synthetic vaccines […

Synthetic nanoparticles for vaccines and immunotherapy

DJ Irvine, MC Hanson, K Rakhra, T Tokatlian - Chemical reviews, 2015 - ACS Publications
… B cells play a canonical role in vaccine responses by … synthetic nanoparticles have the
prospect to play a significant role in the ongoing revolution of immunology in medicine—vaccines

Engineering synthetic vaccines using cues from natural immunity

DJ Irvine, MA Swartz, GL Szeto - Nature materials, 2013 - nature.com
… In addition to aiding cross-presentation of whole-protein antigens, an important recent
advance has been the demonstration in small animal models that synthetic nanoparticles can …

Emerging advances in synthetic cancer nano-vaccines: opportunities and challenges

MZ Ahmad, J Ahmad, A Haque… - … review of vaccines, 2020 - Taylor & Francis
Nanoparticles (NPs) vaccine delivery overcome the restriction of the instability of soluble
macromolecular components, low cellular internalization of soluble materials, and …

Synthetic vaccine nanoparticles target to lymph node triggering enhanced innate and adaptive antitumor immunity

SY Kim, YW Noh, TH Kang, JE Kim, S Kim, SH Um… - Biomaterials, 2017 - Elsevier
… In this study, synthetic vaccine nanoparticles (SVNPs) that efficiently targeted lymph nodes,
… Both preventive and therapeutic vaccination of EG7-OVA tumor-bearing mice using the …

Recent advances in the molecular design of synthetic vaccines

LH Jones - Nature chemistry, 2015 - nature.com
… A non-viral vaccine platform was recently developed to deliver synthetic, self-amplifying
mRNA in a lipid nanoparticle (as used for siRNA delivery) for effective preclinical immunizations …

Peptide-based synthetic vaccines

M Skwarczynski, I Toth - Chemical science, 2016 - pubs.rsc.org
… , discuss epitope and adjuvant design, and multi-epitope and nanoparticle-based vaccine
vaccines. It proposes possible methods to overcome the weaknesses of the synthetic vaccine

The immune effects of naturally occurring and synthetic nanoparticles

C Chang - Journal of autoimmunity, 2010 - Elsevier
… With regard to synthetic nanoparticles, many food additives contain large amounts of
particles in this size range with active highly charged surface molecules, and this may lead to …

Synthetic vaccine characterization and design

R Zhang, BD Ulery - Journal of Bionanoscience, 2018 - ingentaconnect.com
… can be used to characterize synthetic vaccines. In addition, some important synthetic vaccine
design rules … Specifically, synthetic vaccine systems such as polymeric nanoparticles,5 7–9 …

Gold nanoparticles as carriers for a synthetic Streptococcus pneumoniae type 14 conjugate vaccine

D Safari, M Marradi, F Chiodo, HA Th Dekker… - …, 2012 - Taylor & Francis
… example of a fully synthetic carbohydrate vaccine based on gold … nanoparticles as a versatile
platform for the development of a great diversity of synthetic carbohydrate-based vaccines. …