Assessing flood risk is challenging due to complex interactions among flood susceptibility, hazard, exposure, and vulnerability parameters. This study presents a novel flood risk assessment framework by utilizing a hybridized deep neural network (DNN) and fuzzy analytic hierarchy process (AHP) models. Bangladesh was selected as a case study region, where limited studies examined flood risk at a national scale. The results exhibited that hybridized DNN and fuzzy AHP models can produce the most accurate flood risk map while comparing among 15 different models. About 20.45% of Bangladesh are at flood risk zones of moderate, high, and very high severity. The northeastern region, as well as areas adjacent to the Ganges–Brahmaputra–Meghna rivers, have high flood damage potential, where a significant number of people were affected during the 2020 flood event. The risk assessment framework developed in this study would help policymakers formulate a comprehensive flood risk management system.