Managing multiple scales of climate knowledge and decision‐making has proven key to providing useful climate information for decision support. In this chapter, we use specific examples from the work of the Western Water Assessment (WWA) Regional Integrated Sciences and Assessments (RISA) to illustrate how boundary work, consisting of convening, translating, collaborating, and mediating, can help a research organization overcome the challenges that arise from mismatches between scales of knowledge and scales of decision‐making. We then use lessons learned from those examples to call for science policies that better promote and support use‐inspired and scale‐sensitive research for decision support.