To assess the role of negative pressure therapy in the treatment of diabetic foot by the evaluation of the time required for healing and the functional outcomes of patients. Prospective study conducted between September 2014 and February 2017 including 31 patients with diabetic foot clinically monitored following NPWT. Vacuum-assisted closure devices (VAC™-Hartman) were used for applying negative pressure to the wound according to the specified settings (negative pressure, time of use of a kit) in accordance with patients' outcome. The following were monitored: changes in wound size, their bacterial load, and duration of treatment. Healing was obtained in all cases, with an average hospital stay of 27.3 days and 8 days of therapy application. Negative bacterial wound culture results were obtained after an average of 6.45 days by the simultaneous application of negative pressure and antibiotic treatment according to the antibiogram. Skin grafts were necessary to close the defect in 4 cases. After the basic wound treatment, auxiliary methods such as negative pressure contribute to healing. In patients with diabetic foot who required surgical intervention, the use of negative pressure therapy yielded a significant benefit in the preservation of the affected limb, after minimal excision. The results obtained throughout our experience recommend the use of NPWT technique as indication for abdominal wall surgery in closing abdominal wall defects, compartment syndrome and surgical site infection after prosthetic mesh.