Network analysis and transcriptome profiling identify autophagic and mitochondrial dysfunctions in SARS-CoV-2 infection
Analyzing host cells' transcriptional response to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection will help delineate biological processes underlying
viral pathogenesis. First, analysis of expression profiles of lung cell lines A549 and Calu3
revealed upregulation of antiviral interferon signaling genes in response to all three SARS-
CoV-2, MERS-CoV, or influenza A virus (IAV) infections. However, perturbations in
expression of genes involved in inflammatory, mitochondrial, and autophagy processes …
coronavirus 2 (SARS-CoV-2) infection will help delineate biological processes underlying
viral pathogenesis. First, analysis of expression profiles of lung cell lines A549 and Calu3
revealed upregulation of antiviral interferon signaling genes in response to all three SARS-
CoV-2, MERS-CoV, or influenza A virus (IAV) infections. However, perturbations in
expression of genes involved in inflammatory, mitochondrial, and autophagy processes …
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