Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social interactions
RS Ehrlichman, SN Luminais, SL White, ND Rudnick… - Brain research, 2009 - Elsevier
INTRODUCTION: Neuregulin-1 (NRG1) is one of susceptibility genes for schizophrenia and
plays critical roles in glutamatergic, dopaminergic and GABAergic signaling. Using mutant
mice heterozygous for Nrg1 (Nrg1+/−) we studied the effects of Nrg1 signaling on behavioral
and electrophysiological measures relevant to schizophrenia. EXPERIMENTAL
PROCEDURE: Behavior of Nrg1+/− mice and their wild type littermates was evaluated using
pre-pulse inhibition, contextual fear conditioning, novel object recognition, locomotor, and …
plays critical roles in glutamatergic, dopaminergic and GABAergic signaling. Using mutant
mice heterozygous for Nrg1 (Nrg1+/−) we studied the effects of Nrg1 signaling on behavioral
and electrophysiological measures relevant to schizophrenia. EXPERIMENTAL
PROCEDURE: Behavior of Nrg1+/− mice and their wild type littermates was evaluated using
pre-pulse inhibition, contextual fear conditioning, novel object recognition, locomotor, and …
[PDF][PDF] Neuregulin 1 transgenic mice display reduced mismatch negativity, contextual fear conditioning and social...
Abstract Introduction—Neuregulin-1 (NRG1) is one of susceptibility genes for schizophrenia
and plays critical roles in glutamatergic, dopaminergic and GABAergic signaling. Using
mutant mice heterozygous for Nrg1 (Nrg1+/−) we studied the effects of Nrg1 signaling on
behavioral and electrophysiological measures relevant to schizophrenia. Experimental
Procedure—Behavior of Nrg1+/− mice and their wild type littermates was evaluated using
pre-pulse inhibition, contextual fear conditioning, novel object recognition, locomotor, and …
and plays critical roles in glutamatergic, dopaminergic and GABAergic signaling. Using
mutant mice heterozygous for Nrg1 (Nrg1+/−) we studied the effects of Nrg1 signaling on
behavioral and electrophysiological measures relevant to schizophrenia. Experimental
Procedure—Behavior of Nrg1+/− mice and their wild type littermates was evaluated using
pre-pulse inhibition, contextual fear conditioning, novel object recognition, locomotor, and …
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