Neurobiological effects of Hyperforin and its potential in Alzheimer's disease therapy
TN Griffith, L Varela-Nallar… - Current medicinal …, 2010 - ingentaconnect.com
St. John's Wort (SJW) has been used medicinally for over 5,000 years. Relatively recently,
one of its phloroglucinol derivatives, hyperforin, has emerged as a compound of interest.
Hyperforin first gained attention as the constituent of SJW responsible for its antidepressant
effects. Since then, several of its neurobiological effects have been described, including
neurotransmitter re-uptake inhibition, the ability to increase intracellular sodium and calcium
levels, canonical transient receptor potential 6 (TRPC6) activation, N-methyl-D-aspartic acid …
one of its phloroglucinol derivatives, hyperforin, has emerged as a compound of interest.
Hyperforin first gained attention as the constituent of SJW responsible for its antidepressant
effects. Since then, several of its neurobiological effects have been described, including
neurotransmitter re-uptake inhibition, the ability to increase intracellular sodium and calcium
levels, canonical transient receptor potential 6 (TRPC6) activation, N-methyl-D-aspartic acid …
[引用][C] Neurobiological effects of hyperforin and its potential in alzheimers disease therapy
M Dinamarca-Ceballos, T Griffith, N Inestrosa-Cantin… - 2010
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