Activation of the endoplasmic reticulum (ER) stress and ER stress response, also known as
the unfolded protein response (UPR), is common to various degenerative disorders.
Therefore, signaling components of the UPR are currently emerging as potential targets for
intervention and treatment of human diseases. One UPR signaling member, activating
transcription factor 4 (ATF4), has been found up-regulated in many pathological conditions,
pointing to therapeutic potential in targeting its expression. In cells, ATF4 governs multiple …