Neurodegenerative changes in serum IgG antibodies to GD1a, GM1 and GM3 gangliosides in aging rats
V Kolyovska, V Pavlova, I Iliev… - American Journal of …, 2015 - ingentaconnect.com
V Kolyovska, V Pavlova, I Iliev, Y Dokova, D Maslarov
American Journal of Neuroprotection and Neuroregeneration, 2015•ingentaconnect.comObjectives: We measure IgG gangliosides antibodies titers in rats sera. Background: The
complex of anti-gangliosides antibodies may be useful diagnostic and prognostic markers of
the neurodegeneration (GD1a), demyelination (GM1) and correlated with the loss of integrity
of the blood brain barrier (GM3). Methods: The values of IgG anti-GD1a, anti-GM1 and anti-
GM3 antibodies titers were detected by ELISA in the rats (1, 13, 18, 22, 30, 33 months of
age). Results: Significantly elevated serum IgG anti-GD1a, anti-GM1 and anti-GM3 …
complex of anti-gangliosides antibodies may be useful diagnostic and prognostic markers of
the neurodegeneration (GD1a), demyelination (GM1) and correlated with the loss of integrity
of the blood brain barrier (GM3). Methods: The values of IgG anti-GD1a, anti-GM1 and anti-
GM3 antibodies titers were detected by ELISA in the rats (1, 13, 18, 22, 30, 33 months of
age). Results: Significantly elevated serum IgG anti-GD1a, anti-GM1 and anti-GM3 …
Objectives
We measure IgG gangliosides antibodies titers in rats sera.
Background
The complex of anti-gangliosides antibodies may be useful diagnostic and prognostic markers of the neurodegeneration (GD1a), demyelination (GM1) and correlated with the loss of integrity of the blood brain barrier (GM3).
Methods
The values of IgG anti-GD1a, anti-GM1 and anti-GM3 antibodies titers were detected by ELISA in the rats (1, 13, 18, 22, 30, 33 months of age).
Results
Significantly elevated serum IgG anti-GD1a, anti-GM1 and anti-GM3 antibodies titers were detected in rats at age only over 18 months. At 18 and 22 monthly rats significant increase in titer of antibodies against GD1a was shown. At 30 and 33 monthly rats significant increase in the serum titer of antibodies against GM1 and GM3 was shown.
Conclusions
Our results suggest that it is possible to use the serum IgG antibodies as biomarkers for neurodegeneration, demyelination and the damage of the integrity of the blood brain barrier. The value of the titer of IgG antibodies against GD1a, GM1 and GM3 ganglioside showed the presence of immunological mediated neurodegeneration, concomitant demyelination, growing with age, and impaired the integrity of the blood brain barrier. The observed changes are evidence of age-related neurodegenerative changes.
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