Neuromuscular electrical stimulation improves skeletal muscle regeneration through satellite cell fusion with myofibers in healthy elderly subjects
ES Di Filippo, R Mancinelli… - Journal of Applied …, 2017 - journals.physiology.org
The aim of this study was to determine whether neuromuscular electrical stimulation (NMES)
affects skeletal muscle regeneration through a reduction of oxidative status in satellite cells
of healthy elderly subjects. Satellite cells from the vastus lateralis skeletal muscle of 12
healthy elderly subjects before and after 8 wk of NMES were allowed to proliferate to provide
myogenic populations of adult stem cells [myogenic precursor cells (MPCs)]. These MPCs
were then investigated in terms of their proliferation, their basal cytoplasmic free Ca2+ …
affects skeletal muscle regeneration through a reduction of oxidative status in satellite cells
of healthy elderly subjects. Satellite cells from the vastus lateralis skeletal muscle of 12
healthy elderly subjects before and after 8 wk of NMES were allowed to proliferate to provide
myogenic populations of adult stem cells [myogenic precursor cells (MPCs)]. These MPCs
were then investigated in terms of their proliferation, their basal cytoplasmic free Ca2+ …
Neuromuscular electrical stimulation improves skeletal muscle regeneration 1 through satellite cell fusion with myofibers in healthy elderly subjects 2
V dei Vestini - journals.physiology.org
The NMES effect on skeletal muscle regeneration was assessed on healthy elderly 53 for
the first time. NMES improved the regenerative capacity of skeletal muscle 54 through
increased MPC proliferation and fusion with mature myofibers. The 55 increased [Ca2+] cyt
along with MYOD, MYOG and miRNAs up-regulation could be 56 related to reduced O2•–
production, which, in turn, favors myogenic regeneration. 57 Accordingly, the skeletal
muscle strength of NMES-stimulated lower limbs of healthy 58 elderly subjects improved …
the first time. NMES improved the regenerative capacity of skeletal muscle 54 through
increased MPC proliferation and fusion with mature myofibers. The 55 increased [Ca2+] cyt
along with MYOD, MYOG and miRNAs up-regulation could be 56 related to reduced O2•–
production, which, in turn, favors myogenic regeneration. 57 Accordingly, the skeletal
muscle strength of NMES-stimulated lower limbs of healthy 58 elderly subjects improved …
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