[HTML][HTML] Neuropathic pain changes the output of rat lamina I spino-parabrachial neurons
BBA advances, 2023•Elsevier
Spared nerve injury (SNI) altered the action potential (AP) output of lamina I spino-
parabrachial neurons (SPNs) without affecting their resting potential or membrane
resistance.• In one-third of SPNs, high-threshold dorsal root stimulation elicited persistent AP
firing which was never observed in cells from naïve animals.• 38% of SPNs from SNI rats
showed spontaneous persistent AP firing.• After SNI low-and high-output SPNs were no
longer nociceptive-specific as part of them responded with APs to low-threshold stimulation.• …
parabrachial neurons (SPNs) without affecting their resting potential or membrane
resistance.• In one-third of SPNs, high-threshold dorsal root stimulation elicited persistent AP
firing which was never observed in cells from naïve animals.• 38% of SPNs from SNI rats
showed spontaneous persistent AP firing.• After SNI low-and high-output SPNs were no
longer nociceptive-specific as part of them responded with APs to low-threshold stimulation.• …
Abstract
• Spared nerve injury (SNI) altered the action potential (AP) output of lamina I spino-parabrachial neurons (SPNs) without affecting their resting potential or membrane resistance.
• In one-third of SPNs, high-threshold dorsal root stimulation elicited persistent AP firing which was never observed in cells from naïve animals.
• 38% of SPNs from SNI rats showed spontaneous persistent AP firing.
• After SNI low- and high-output SPNs were no longer nociceptive-specific as part of them responded with APs to low-threshold stimulation.
• These SNI-induced changes of SPN output might represent cellular mechanisms for neuropathy-associated allodynia, hyperalgesia, and spontaneous pain.
Elsevier
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