Recent evidence has implicated the transmembrane co-receptor neuropilin-1 (NRP1) in
cancer progression. Primarily known as a regulator of neuronal guidance and angiogenesis,
NRP1 is also expressed in multiple human malignancies, where it promotes tumor
angiogenesis. However, non-angiogenic roles of NRP1 in tumor progression remain poorly
characterized. In this study, we define NRP1 as an androgen-repressed gene whose
expression is elevated during the adaptation of prostate tumors to androgen-targeted …

Abstract Aims: Androgen-targeted therapies (ATTs) are the mainstay treatment for metastatic
prostate cancer (PCa). However, ATTs promote adaptation of tumour cells and lead to
castration resistant disease (CRPC). We have recently identified the cell surface receptor,
Neuropilin-1 (NRP1) as increased during EMT and in CRPC. However, the role of NRP1 in
the prostate epithelium is poorly understood. This study aims to determine whether the
inhibition of NRP1 will be a feasible therapeutic strategy for blocking PCa metastasis and …