Neuropsychiatric disorders in Cushing's syndrome

R Pivonello, C Simeoli, MC De Martino… - Frontiers in …, 2015 - frontiersin.org
Endogenous Cushing's syndrome (CS), a rare endocrine disorder characterized by cortisol
hypersecretion, is associated with psychiatric and neurocognitive disorders. Major
depression, mania, anxiety, and neurocognitive impairment are the most important clinical
abnormalities. Moreover, patients most often complain of impairment in quality of life,
interference with family life, social, and work performance. Surprisingly, after
hypercortisolism resolution, despite the improvement of the overall prevalence of psychiatric …

Neuropsychiatric disorders in Cushing's syndrome

AM Pereira, J Tiemensma, JA Romijn - Neuroendocrinology, 2010 - karger.com
Glucocorticoids are crucial in the initiation and consolidation of the stress response. Patients
with active Cushing's syndrome (CS) are exposed to excessive endogenous glucocorticoid
levels. In these patients, psychopathology is often being observed. The most common co-
morbid disorder is major depression, but to a lesser extent mania and anxiety disorders
have also been reported. A severe clinical presentation of CS often also includes
depression. Reduction of glucocorticoid synthesis or action, either with metyrapone …
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