Memory dysfunction is a symptomatic feature of many neurologic and neuropsychiatric
disorders; however, the basic underlying mechanisms of memory and altered states of
circuitry function associated with disorders of memory remain a vast unexplored territory.
The initial discovery of endogenous neurosteroids triggered a quest to elucidate their role as
neuromodulators in normal and diseased brain function. In this review, based on the
perspective of our own research, the advances leading to the discovery of positive and …