BACKGROUND The setting of a randomized trial can determine whether its findings are
generalizable and can therefore apply to different settings. The contribution of low-and
middle-income countries (LMICs) to neurosurgical randomized trials has not been
systematically described before. OBJECTIVE To perform a systematic analysis of design
characteristics and methodology, funding source, and interventions studied between trials
led by and/or conducted in high-income countries (HICs) vs LMICs. METHODS From …