New cholinesterase inhibiting bisbenzylisoquinoline alkaloids from Abuta grandifolia

MF Cometa, S Fortuna, G Palazzino, MT Volpe… - Fitoterapia, 2012 - Elsevier
The phytochemical study of the stem bark and wood of Abuta grandifolia (Mart.) Sandwith
led to the identification of four bisbenzylisoquinoline alkaloids (BBIQs), namely (R, S)-2 N-
norberbamunine (1),(R, R)-isochondodendrine (2),(SS)-O4 ″-methyl, Nb-nor-O6′-
demethyl-(+)-curine (3), and (SS)-O4 ″-methyl, O6′-demethyl-(+)-curine (4), together with
the aporphine alkaloid R-nornuciferine (5), all obtained by countercurrent distribution
separation (CCD) and identified on the basis of their spectroscopic data. Alkaloids 3 and 4 …
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