New fragmentation mechanisms in matrix‐assisted laser desorption/ionization time‐of‐flight/time‐of‐flight tandem mass spectrometry of carbohydrates
E Spina, L Sturiale, D Romeo… - Rapid …, 2004 - Wiley Online Library
Rapid Communications in Mass Spectrometry, 2004•Wiley Online Library
The spectra recorded by matrix‐assisted laser desorption/ionization time‐of‐flight/time‐of‐
flight tandem mass spectrometry (MALDI‐TOF/TOF‐MS/MS) of complex carbohydrates from
human milk are presented. Besides ions originating from glycosidic cleavages and from
sugar ring fragmentations, these spectra show intense peaks that may be assigned to ions
produced by three new fragmentation pathways involving a six‐atom rearrangement. These
ions, together with the A fragments from sugar ring fragmentations, open the possibility of …
flight tandem mass spectrometry (MALDI‐TOF/TOF‐MS/MS) of complex carbohydrates from
human milk are presented. Besides ions originating from glycosidic cleavages and from
sugar ring fragmentations, these spectra show intense peaks that may be assigned to ions
produced by three new fragmentation pathways involving a six‐atom rearrangement. These
ions, together with the A fragments from sugar ring fragmentations, open the possibility of …
Abstract
The spectra recorded by matrix‐assisted laser desorption/ionization time‐of‐flight/time‐of‐flight tandem mass spectrometry (MALDI‐TOF/TOF‐MS/MS) of complex carbohydrates from human milk are presented. Besides ions originating from glycosidic cleavages and from sugar ring fragmentations, these spectra show intense peaks that may be assigned to ions produced by three new fragmentation pathways involving a six‐atom rearrangement. These ions, together with the A fragments from sugar ring fragmentations, open the possibility of obtaining a complete mapping of the linkage positions present in the carbohydrates investigated by MALDI‐TOF/TOF. Copyright © 2004 John Wiley & Sons, Ltd.
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