New Isomalabaricane Triterpenes from the Marine Sponge Stelletta globostellata That Induce Morphological Changes in Rat Fibroblasts
N Oku, S Matsunaga, S Wada, S Watabe… - Journal of natural …, 2000 - ACS Publications
N Oku, S Matsunaga, S Wada, S Watabe, N Fusetani
Journal of natural products, 2000•ACS PublicationsThree new isomalabaricane triterpenes, 29-hydroxystelliferin D (2), 3-epi-29-
hydroxystelliferin E (3), and 3-epi-29-hydroxystelliferin A (4), were isolated from the marine
sponge Stelletta globostellata. Their structures, including absolute stereochemistry, were
determined on the basis of spectral data and chemical methods. Rat fibroblasts treated with
0.2 μM of 2− 4 exhibited unusual morphological characteristics, followed by death in 5 days.
hydroxystelliferin E (3), and 3-epi-29-hydroxystelliferin A (4), were isolated from the marine
sponge Stelletta globostellata. Their structures, including absolute stereochemistry, were
determined on the basis of spectral data and chemical methods. Rat fibroblasts treated with
0.2 μM of 2− 4 exhibited unusual morphological characteristics, followed by death in 5 days.
Three new isomalabaricane triterpenes, 29-hydroxystelliferin D (2), 3-epi-29-hydroxystelliferin E (3), and 3-epi-29-hydroxystelliferin A (4), were isolated from the marine sponge Stelletta globostellata. Their structures, including absolute stereochemistry, were determined on the basis of spectral data and chemical methods. Rat fibroblasts treated with 0.2 μM of 2−4 exhibited unusual morphological characteristics, followed by death in 5 days.
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