Aim To evaluate “ex ante” the predictive factors of incomplete/absent response to the
standard therapy in a well characterized series of Autoimmune Hepatitis (AIH) patients from
Italy. Methods Of 282 AIH patients screened from our database 166 (59%) had a sustained
response and 116 (41%) had an incomplete/absent response to the therapy; all patients
were analyzed for the clinical, serological and histological parameters at diagnosis. Results
The patients with incomplete/absent response were characterized by significantly younger …

Results Patients were classified into two groups; group A showed a complete response to
therapy (n= 22; 61%) and group B showed partial response/treatment failure (n= 14; 39%).
In a multivariate analysis, we observed that age at diagnosis up to 22 years [odds ratio (OR):
23.22; confidence interval (CI): 3.978–135.549; P< 0.001], serum albumin up to 3.2 g/dl (OR:
5.36; CI: 1.237–23.209; P= 0.025), mean platelet volume (MPV) of at least 10.75 fl (OR: 16.5;
CI: 3.093–88.037; P< 0.001), and presence of cirrhosis at diagnosis (OR: 8.44; CI: 1.682 …