New roles for G-protein (βγ-dimers in transmembrane signalling
DE Clapham, EJ Neer - Nature, 1993 - nature.com
DE Clapham, EJ Neer
Nature, 1993•nature.comWhen a membrane-bound receptor acts on a G protein, the GTP-binding or G α subunit
dissociates from the G βγ dimer. Until recently, the G α subunit alone was thought to act on
the enzymes and ion channels controlled by these proteins. Newer evidence indicates that
the G βγ. dimer also plays a major part in signal transmission, enhancing the complexity of
the possible interactions between the G proteins and their targets.
dissociates from the G βγ dimer. Until recently, the G α subunit alone was thought to act on
the enzymes and ion channels controlled by these proteins. Newer evidence indicates that
the G βγ. dimer also plays a major part in signal transmission, enhancing the complexity of
the possible interactions between the G proteins and their targets.
Abstract
When a membrane-bound receptor acts on a G protein, the GTP-binding or Gα subunit dissociates from the Gβγ dimer. Until recently, the Gα subunit alone was thought to act on the enzymes and ion channels controlled by these proteins. Newer evidence indicates that the Gβγ. dimer also plays a major part in signal transmission, enhancing the complexity of the possible interactions between the G proteins and their targets.
nature.com
以上显示的是最相近的搜索结果。 查看全部搜索结果