Background: Reconstruction in the setting of prior breast irradiation is conventionally
considered a higher-risk procedure. Limited data exist regarding nipple-sparing mastectomy
in irradiated breasts, a higher-risk procedure in higher-risk patients. Methods: The authors
identified and reviewed the records of 501 nipple-sparing mastectomy breasts at their
institution from 2006 to 2013. Results: Of 501 nipple-sparing mastectomy breasts, 26 were
irradiated. The average time between radiation and mastectomy was 12 years …

… They highlight the unique scenario that nipple-sparing mastectomies present with combining
absence skin deficiencies with the increased risks inherent in the technique of nipple-sparing
mastectomy coupled with potential perfusion and compliance challenges of previously irradiated
tissues. Although reconstruction in the setting of … Alperovich et al. show that immediate
reconstruction in previously irradiated nipple-sparing mastectomy has no significantly
higher rates of complication than nonirradiated nipple-sparing mastectomy. We commend …