Nitric oxide in the regulation of body temperature and fever

AA Steiner, LGS Branco - Journal of Thermal Biology, 2001 - Elsevier
Journal of Thermal Biology, 2001Elsevier
(1) In this article, the aspects regarding the role of nitric oxide (NO) in thermoregulation and
fever is reviewed.(2) It is currently believed that fever results from de novo synthesis of
cytokines and subsequent stimulation of the generation of prostaglandins in the central
nervous system. However, the mechanisms underlying fever still remain only partly
understood.(3) Recently, a new biologically active molecule has been described, ie, the
gaseous compound NO. This molecule started a revolution in the understanding of several …
(1) In this article, the aspects regarding the role of nitric oxide (NO) in thermoregulation and fever is reviewed. (2) It is currently believed that fever results from de novo synthesis of cytokines and subsequent stimulation of the generation of prostaglandins in the central nervous system. However, the mechanisms underlying fever still remain only partly understood. (3) Recently, a new biologically active molecule has been described, i.e., the gaseous compound NO. This molecule started a revolution in the understanding of several physiological and pathophysiological processes, including thermoregulation and fever.
Elsevier
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