Nitroprusside enhances isoprenaline-induced increases in cAMP in rat aortic smooth muscle
DH Maurice, RJ Haslam - European journal of pharmacology, 1990 - Elsevier
DH Maurice, RJ Haslam
European journal of pharmacology, 1990•ElsevierLow concentrations of sodium nitroprusside (SNP) and of isoprenaline acted synergistically
to inhibit the phenylephrine-induced contraction of rat aortic smooth muscle. In experiments
with these concentrations, SNP enhanced the increases in smooth muscle cAMP caused by
isoprenaline by 4-to 5-fold, whereas the SNP-induced increases in tissue cGMP were
unaffected by isoprenaline. We conclude that cAMP is likely to mediate the synergistic
inhibition of the contraction of rat aortic smooth muscle by these compounds.
to inhibit the phenylephrine-induced contraction of rat aortic smooth muscle. In experiments
with these concentrations, SNP enhanced the increases in smooth muscle cAMP caused by
isoprenaline by 4-to 5-fold, whereas the SNP-induced increases in tissue cGMP were
unaffected by isoprenaline. We conclude that cAMP is likely to mediate the synergistic
inhibition of the contraction of rat aortic smooth muscle by these compounds.
Abstract
Low concentrations of sodium nitroprusside (SNP) and of isoprenaline acted synergistically to inhibit the phenylephrine-induced contraction of rat aortic smooth muscle. In experiments with these concentrations, SNP enhanced the increases in smooth muscle cAMP caused by isoprenaline by 4- to 5-fold, whereas the SNP-induced increases in tissue cGMP were unaffected by isoprenaline. We conclude that cAMP is likely to mediate the synergistic inhibition of the contraction of rat aortic smooth muscle by these compounds.
Elsevier