Truncated soluble Nogo receptor binds Nogo-66 and blocks inhibition of axon growth by myelin

AE Fournier, GC Gould, BP Liu… - Journal of …, 2002 - Soc Neuroscience
… it participates in Nogo-dependent inhibition of axon growth. E7 retinal … Model of Nogo
receptor-mediated signaling. This schematic illustrates … and by diffusible blockade of NgR action. …

The soluble form of LOTUS inhibits Nogo receptor-mediated signaling by interfering with the interaction between Nogo receptor type 1 and p75 neurotrophin receptor

Y Kawakami, Y Kurihara, Y Saito, Y Fujita… - Journal of …, 2018 - Soc Neuroscience
growth cone collapse in these neurons. Finally, we observed that s-LOTUS promoted
axonal … s-LOTUS compensates for the blockade of MAI-induced growth cone collapse by the …

Axonal regeneration and functional recovery driven by endogenous Nogo receptor antagonist LOTUS in a rat model of unilateral pyramidotomy

R Ueno, H Takase, J Suenaga, M Kishimoto… - Experimental …, 2020 - Elsevier
… Myelin fragments contain axonal growth inhibitors that limit axonal regeneration, thus … Nogo
receptor-1 (NgR1) and its ligands are among the inhibitors that limit axonal regeneration. It …

Nogo-A stabilizes the architecture of hippocampal neurons

M Zagrebelsky, R Schweigreiter… - Journal of …, 2010 - Soc Neuroscience
… Neutralization of Nogo-A by function-blocking antibodies … of Nogo-A from an environmental,
receptor-mediated function… first examined axonal morphology of CA3 axons in which Nogo-A …

Pincher-generated Nogo-A endosomes mediate growth cone collapse and retrograde signaling

A Joset, DA Dodd, S Halegoua, ME Schwab - Journal of Cell Biology, 2010 - rupress.org
Nogo-A is one of the most potent myelin-associated inhibitors for axonal growth, … cone
response of hippocampal neurons after blocking NogoΔ20 endocytosis. Dissociated E19 …

Axon growth inhibition by RhoA/ROCK in the central nervous system

Y Fujita, T Yamashita - Frontiers in neuroscience, 2014 - frontiersin.org
… effects of myelin-associated axon growth inhibitors—Nogo, myelin-… Blocking RhoA/ROCK
signaling can reverse the inhibitory … Blocking LAR with a peptide enhances axonal growth of …

Counteraction of Nogo-A and axonal growth inhibitors by green tea polyphenols and other natural products

TK Fan, U Gundimeda, WJ Mack… - Neural regeneration …, 2016 - journals.lww.com
… for blocking NgR1 or its downstream signaling to enhance … to receptor-mediated actions
of EGCG may inhibit RhoA through a redox sensitive mechanism and thereby block Nogo-A …

Targeting neurite growth inhibitors to induce CNS regeneration

AJ Kastin, W Pan - Current pharmaceutical design, 2005 - ingentaconnect.com
Nogo will refer to Nogo-A. However, Nogo-C has been shown to be capable of delaying axonal
… spinal cord by a saturable, receptor-mediated transport system that could be responsive …

Amino-terminal proteolytic fragment of the axon growth inhibitor Nogo-A (Rtn4A) is upregulated by injury and promotes axon regeneration

Y Sekine, X Wang, K Kikkawa, S Honda… - Journal of Biological …, 2023 - ASBMB
… and endogenous full-length Nogo-A, was found in the axon shafts and the growth cones. Thus,
growth cone, where it acts intracellularly to enhance axonal regeneration. Nogo-A amino-…

Genetic deletion and pharmacological inhibition of Nogo-66 receptor impairs cognitive outcome after traumatic brain injury in mice

A Hånell, F Clausen, M Björk, K Jansson… - Journal of …, 2010 - liebertpub.com
… in p75/nogo receptor-mediated RhoA … Blockade of Nogo-66, myelin-associated glycoprotein,
and oligodendrocyte myelin glycoprotein by soluble Nogo-66 receptor promotes axonal