Nomimicin, a new spirotetronate-class polyketide from an actinomycete of the genus Actinomadura

Y Igarashi, T Iida, N Oku, H Watanabe… - The Journal of …, 2012 - nature.com
Y Igarashi, T Iida, N Oku, H Watanabe, K Furihata, K Miyanouchi
The Journal of Antibiotics, 2012nature.com
Abstract Nomimicin (1), a new spirotetronate-class polyketide, was isolated from the culture
broth of an actinomycete of the genus Actinomadura. Its structure was established by
spectroscopic methods, and the absolute configuration was determined by a combination of
NOESY experiment, J-based configuration analysis and the modified Mosher method.
Nomimicin (1) showed antimicrobial activity against Micrococcus luteus, Candida albincans
and Kluyveromyces fragilis.
Abstract
Nomimicin (1), a new spirotetronate-class polyketide, was isolated from the culture broth of an actinomycete of the genus Actinomadura. Its structure was established by spectroscopic methods, and the absolute configuration was determined by a combination of NOESY experiment, J-based configuration analysis and the modified Mosher method. Nomimicin (1) showed antimicrobial activity against Micrococcus luteus, Candida albincans and Kluyveromyces fragilis.
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