Non-functioning adrenal incidentalomas may increase toxic metabolites

I Karahan, S Durmaz Ceylan, A Gungunes… - Wiener klinische …, 2022 - Springer
I Karahan, S Durmaz Ceylan, A Gungunes, A Cifci, F Eker, U Kisa
Wiener klinische Wochenschrift, 2022•Springer
Background Non-functioning adrenal incidentaloma (NFAI) is a frequent diagnosis with
increasing radiological tests. The emerging shreds of evidence showed that they might have
negative cardiometabolic effects. The study aimed to investigate whether the toxic
metabolites, asymmetric dimethylarginine (ADMA) levels, were altered in NFAI patients.
Methods We included 43 NFAI patients and 41 controls with similar ages and body mass
indices in the study. We compared plasma ADMA levels of both groups and noted the …
Background
Non-functioning adrenal incidentaloma (NFAI) is a frequent diagnosis with increasing radiological tests. The emerging shreds of evidence showed that they might have negative cardiometabolic effects. The study aimed to investigate whether the toxic metabolites, asymmetric dimethylarginine (ADMA) levels, were altered in NFAI patients.
Methods
We included 43 NFAI patients and 41 controls with similar ages and body mass indices in the study. We compared plasma ADMA levels of both groups and noted the radiological features of NFAIs.
Results
The ADMA levels were significantly higher in NFAI patients than in the control group (307.04 ng/ml, range 81.89–577.7 ng/ml vs 192.54 ng/ml, range 70.61–440.26 ng/ml, p = 0.001). Nevertheless, we could not reach a significant correlation between ADMA levels and mass size.
Conclusion
The ADMA is known as a toxin and is increased in NFAI patients. NFAIs may not be innocent and may be considered a potential risk for the body. Further investigations were needed for more explanations.
Springer
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