Somatic intrachromosomal recombination can result in inversions and deletions in DNA,
which are important mutations in cancer. The pKZ1 chromosomal inversion assay is a
sensitive assay for studying the effects of DNA damaging agents using chromosomal
inversion as a mutation end-point. We have previously demonstrated that the chromosomal
inversion response in pKZ1 spleen after single low doses of X-radiation exposure does not
follow the linear no-threshold dose–response model. Here, we optimised a chromosomal …