Noninvasive, transcranial and localized opening of the blood-brain barrier using focused ultrasound in mice
The feasibility of blood-brain barrier (BBB) opening in the hippocampus of wild-type mice
using focused ultrasound (FUS) through the intact skull and skin was investigated. Needle
hydrophone measurements through ex vivo skulls revealed minimal attenuation (∼ 18% of
the pressure amplitude), a well-focused beam pattern and minute focus displacement
through the parietal bone. In experiments in vivo, the brains of three mice were sonicated
transcranially. Pulsed ultrasound sonications at 1.5 MHz and acoustic pressures ranging …
using focused ultrasound (FUS) through the intact skull and skin was investigated. Needle
hydrophone measurements through ex vivo skulls revealed minimal attenuation (∼ 18% of
the pressure amplitude), a well-focused beam pattern and minute focus displacement
through the parietal bone. In experiments in vivo, the brains of three mice were sonicated
transcranially. Pulsed ultrasound sonications at 1.5 MHz and acoustic pressures ranging …
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