Noninvasive assessment of murine pulmonary arterial pressure: validation and application to models of pulmonary hypertension
HB Thibault, B Kurtz, MJ Raher, RS Shaik… - Circulation …, 2010 - Am Heart Assoc
Background—Genetically modified mice offer the unique opportunity to gain insight into the
pathophysiology of pulmonary arterial hypertension. In mice, right heart catheterization is the
only available technique to measure right ventricular systolic pressure (RVSP). However, it
is a terminal procedure and does not allow for serial measurements. Our objective was to
validate a noninvasive technique to assess RVSP in mice. Methods and Results—Right
ventricle catheterization and echocardiography (30-MHz transducer) were simultaneously …
pathophysiology of pulmonary arterial hypertension. In mice, right heart catheterization is the
only available technique to measure right ventricular systolic pressure (RVSP). However, it
is a terminal procedure and does not allow for serial measurements. Our objective was to
validate a noninvasive technique to assess RVSP in mice. Methods and Results—Right
ventricle catheterization and echocardiography (30-MHz transducer) were simultaneously …