Normothermic machine perfusion of the kidney

A Weissenbacher, J Hunter - Current opinion in organ …, 2017 - journals.lww.com
… The results of recent large animal experiments and clinical trials show that continuous
prolonged normothermic ex-vivo kidney perfusion appears better than a brief period of NMP
after static cold storage in terms of renal injury and function. A recently developed clinical
scoring system appears to correlate with renal and tubular function. A prospective clinical
phase II trial to investigate the initial graft function after 1 h of NMP or static cold storage in …
After initial efforts of normothermic perfusion and the introduction of hypothermic machine …

Normothermic machine perfusion of the kidney: better conditioning and repair?

SA Hosgood, E van Heurn… - Transplant …, 2015 - Wiley Online Library
Kidney transplantation is limited by hypothermic preservation techniques. Prolonged periods
of cold ischaemia increase the risk of early graft dysfunction and reduce long‐term survival.
To extend the boundaries of transplantation and utilize kidneys from more marginal donors,
improved methods of preservation are required. Normothermic perfusion restores energy
levels in the kidney allowing renal function to be restored ex vivo. This has several
advantages: cold ischaemic injury can be avoided or minimized, the kidney can be …
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