Novel GD-loaded silicon nanohybrid: a potential epidermal growth factor receptor expressing cancer cell targeting magnetic resonance imaging contrast agent
Continuing our research efforts in developing mesoporous silicon nanoparticle-based
biomaterials for cancer therapy, we employed here porous silicon nanoparticles as a
nanocarrier to deliver contrast agents to diseased cells. Nanoconfinement of small molecule
Gd-chelates (L1-Gd) enhanced the T 1 contrast dramatically compared to distinct Gd-chelate
(L1-Gd) by virtue of its slow tumbling rate, increased number of bound water molecules, and
their occupancy time. The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on …
biomaterials for cancer therapy, we employed here porous silicon nanoparticles as a
nanocarrier to deliver contrast agents to diseased cells. Nanoconfinement of small molecule
Gd-chelates (L1-Gd) enhanced the T 1 contrast dramatically compared to distinct Gd-chelate
(L1-Gd) by virtue of its slow tumbling rate, increased number of bound water molecules, and
their occupancy time. The newly synthesized Gd-chelate (L1-Gd) was covalently grafted on …
[引用][C] Novel Gd-Loaded Silicon Nanohybrid: A Potential Epidermal Growth Factor Receptor Expressing Cancer Cell Targeting Magnetic Resonance Imaging Contrast …
S Sougata, TW Yin, MIS JP, P Simon, CR Anna… - 2017
以上显示的是最相近的搜索结果。 查看全部搜索结果