Novel Fe-impregnated BiVO₄ was synthetized by a sonochemistry method, then the Fe-impregnation was prepared through an easy and low-cost method by the directly hydrolyzes iron salt onto BiVO₄ nanoparticles. Scanning electron microscope equipped with an energy dispersive spectrometer analysis indicated the presence of Fe on the impregnated BiVO₄. Half-time of Fe-BiVO₄ (1%) sample was 10 times greater than BiVO₄ pure in the ciprofloxacin degradation by a dual effect process under UV-Vis light irradiation. The dual process synergy was achieved by 55% with respect to photocatalysis, being the predominant process in the degradation by the holes photogenerated corroborating the oxidizing species scavenger's experiments. Novel Fe-BiVO₄ samples can degrade the ciprofloxacin by the dual effect process (photocatalysis and photo-Fenton), which inhibited the electron-hole pairs recombination. 1Fe-BiVO₄ photocatalyst was stable and active after six cycles without presence of photocorrosion. This catalyst may offer a sustainable treatment to decontaminate wastewater.