The design of effective vaccine delivery system is opening up new feasibilities for making
immunization more safe and efficient. In this study, recombinant hepatitis B virus surface
antigen (rHBsAg) was loaded in mannosylated chitosan (MC) nanoparticles to be used as a
targeted vaccine delivery vehicles. The nanoparticles were prepared by ionic gelation
method and characterized for physicochemical properties, cytotoxicity and antigenicity. The
rHBsAg-loaded MC nanoparticles showed spherical shape with mean particle size of …