This paper is concerned with establishing novel expressions that express the derivative of any order of the orthogonal polynomials, namely, Chebyshev polynomials of the sixth kind in terms of Chebyshev polynomials themselves. We will prove that these expressions involve certain terminating hypergeometric functions of the type 4F3(1) that can be reduced in some specific cases. The derived expressions along with the linearization formula of Chebyshev polynomials of the sixth kind serve in obtaining a numerical solution of the non-linear one-dimensional Burgers’ equation based on the application of the spectral tau method. Convergence analysis of the proposed double shifted Chebyshev expansion of the sixth kind is investigated. Numerical results are displayed aiming to show the efficiency and applicability of the proposed algorithm.