Novel imino sugar derivatives demonstrate potent antiviral activity against flaviviruses
Imino sugars, such as N-butyl-deoxynojirimycin and N-nonyl-deoxynojirimycin (NNDNJ), are
glucose analogues that selectively inhibit cellular α-glucosidase I and II in the endoplasmic
reticulum and exhibit antiviral activities against many types of enveloped viruses. Although
these molecules have broad-spectrum antiviral activity, their development has been limited
by a lack of efficacy and/or selectivity. We have previously reported that a DNJ derivative
with a hydroxylated cyclohexyl side chain, called OSL-95II, has an antiviral efficacy similar to …
glucose analogues that selectively inhibit cellular α-glucosidase I and II in the endoplasmic
reticulum and exhibit antiviral activities against many types of enveloped viruses. Although
these molecules have broad-spectrum antiviral activity, their development has been limited
by a lack of efficacy and/or selectivity. We have previously reported that a DNJ derivative
with a hydroxylated cyclohexyl side chain, called OSL-95II, has an antiviral efficacy similar to …
[引用][C] Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity against Dengue Virus
Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity against Dengue Virus -
Drexel University …
Drexel University …
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