Novel mutations in avian PA in combination with an adaptive mutation in PR8 NP exacerbate the virulence of PR8-derived recombinant influenza A viruses in mice
CY Lee, SH An, I Kim, JG Choi, YJ Lee, JH Kim… - Veterinary …, 2018 - Elsevier
The polymerase complex of the low-pathogenic avian influenza virus [A/chicken/Korea/
KBNP-0028/2000](0028) has previously been characterized, and novel amino acid residues
present in the polymerase acidic protein (PA) that likely contribute to pathogenicity toward
mammals have been identified. In the present study, our aims were to generate A/Puerto
Rico/8/34 (PR8)-derived recombinant viruses containing the 0028-PA gene with a single
amino acid mutation and to test their pathogenicity and replication ability. We found that the …
KBNP-0028/2000](0028) has previously been characterized, and novel amino acid residues
present in the polymerase acidic protein (PA) that likely contribute to pathogenicity toward
mammals have been identified. In the present study, our aims were to generate A/Puerto
Rico/8/34 (PR8)-derived recombinant viruses containing the 0028-PA gene with a single
amino acid mutation and to test their pathogenicity and replication ability. We found that the …
Novel mutations in avian PA in combination with an adaptive mutation in PR8 NP exacerbate the virulence of PR8-derived recombinant influenza A viruses in mice.
LCY Lee ChungYoung, ASH An SeHee… - 2018 - cabidigitallibrary.org
The polymerase complex of the low-pathogenic avian influenza virus [A/chicken/Korea/
KBNP-0028/2000](0028) has previously been characterized, and novel amino acid residues
present in the polymerase acidic protein (PA) that likely contribute to pathogenicity toward
mammals have been identified. In the present study, our aims were to generate A/Puerto
Rico/8/34 (PR8)-derived recombinant viruses containing the 0028-PA gene with a single
amino acid mutation and to test their pathogenicity and replication ability. We found that the …
KBNP-0028/2000](0028) has previously been characterized, and novel amino acid residues
present in the polymerase acidic protein (PA) that likely contribute to pathogenicity toward
mammals have been identified. In the present study, our aims were to generate A/Puerto
Rico/8/34 (PR8)-derived recombinant viruses containing the 0028-PA gene with a single
amino acid mutation and to test their pathogenicity and replication ability. We found that the …
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