Novel naphthoquinone derivatives and evaluation of their trypanocidal and leishmanicidal activities
AA dos Santos Naujorks, AO da Silva… - Organic & …, 2015 - pubs.rsc.org
Organic & Biomolecular Chemistry, 2015•pubs.rsc.org
Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1, 4-
naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their
trypanocidal and leishmanicidal activities. Compounds 11a and 13a were active against the
amastigote stage of T. cruzi and showed low cytotoxic effects. With respect to leishmanicidal
assays, all compounds were inactive against the promastigote stages of L. chagasi and L.
braziliensis.
naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their
trypanocidal and leishmanicidal activities. Compounds 11a and 13a were active against the
amastigote stage of T. cruzi and showed low cytotoxic effects. With respect to leishmanicidal
assays, all compounds were inactive against the promastigote stages of L. chagasi and L.
braziliensis.
Herein, we report the synthesis of 12 new naphthoquinone derivatives, 6 substituted 1,4-naphthoquinones and 6 heterocycle-fused naphthoquinones, as well as evaluation of their trypanocidal and leishmanicidal activities. Compounds 11a and 13a were active against the amastigote stage of T. cruzi and showed low cytotoxic effects. With respect to leishmanicidal assays, all compounds were inactive against the promastigote stages of L. chagasi and L. braziliensis.
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