Novel selective calpain 1 inhibitors as potential therapeutics in Alzheimer's disease
M Fa, H Zhang, A Staniszewski… - Journal of …, 2016 - content.iospress.com
Alzheimer's disease, one of the most important brain pathologies associated with
neurodegenerative processes, is related to overactivation of calpain-mediated proteolysis.
Previous data showed a compelling efficacy of calpain inhibition against abnormal synaptic
plasticity and memory produced by the excess of amyloid-ß, a distinctive marker of the
disease. Moreover, a beneficial effect of calpain inhibitors in Alzheimer's disease is
predictable by the occurrence of calpain hyperactivation leading to impairment of memory …
neurodegenerative processes, is related to overactivation of calpain-mediated proteolysis.
Previous data showed a compelling efficacy of calpain inhibition against abnormal synaptic
plasticity and memory produced by the excess of amyloid-ß, a distinctive marker of the
disease. Moreover, a beneficial effect of calpain inhibitors in Alzheimer's disease is
predictable by the occurrence of calpain hyperactivation leading to impairment of memory …
[PDF][PDF] Novel Selective Calpain 1 Inhibitors as Potential Therapeutics in Alzheimer's
MI Siklosc, S Tapadarc, VA Litoshd, J Libiene… - columbianeuroresearch.org
Alzheimer's disease, one of the most important brain pathologies associated with
neurodegenerative processes, is related to overactivation of calpain-mediated proteolysis.
Previous data showed a compelling efficacy of calpain inhibition against abnormal synaptic
plasticity and memory produced by the excess of amyloid-ß, a distinctive marker of the
disease. Moreover, a beneficial effect of calpain inhibitors in Alzheimer's disease is
predictable by the occurrence of calpain hyperactivation leading to impairment of memory …
neurodegenerative processes, is related to overactivation of calpain-mediated proteolysis.
Previous data showed a compelling efficacy of calpain inhibition against abnormal synaptic
plasticity and memory produced by the excess of amyloid-ß, a distinctive marker of the
disease. Moreover, a beneficial effect of calpain inhibitors in Alzheimer's disease is
predictable by the occurrence of calpain hyperactivation leading to impairment of memory …
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