Nrf2-driven TERT regulates pentose phosphate pathway in glioblastoma
Given the involvement of telomerase activation and dysregulated metabolism in glioma
progression, the connection between these two critical players was investigated.
Pharmacological inhibition of human Telomerase reverse transcriptase (hTERT) by
Costunolide induced glioma cell apoptosis in a reactive oxygen species (ROS)-dependent
manner. Costunolide induced an ROS-dependent increase in p53 abrogated telomerase
activity. Costunolide decreased Nrf2 level; and ectopic Nrf2 expression decreased …
progression, the connection between these two critical players was investigated.
Pharmacological inhibition of human Telomerase reverse transcriptase (hTERT) by
Costunolide induced glioma cell apoptosis in a reactive oxygen species (ROS)-dependent
manner. Costunolide induced an ROS-dependent increase in p53 abrogated telomerase
activity. Costunolide decreased Nrf2 level; and ectopic Nrf2 expression decreased …
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