A novel inwardly off-center shearing jet-stirred reactor is proposed and examined computationally. The inwardly off-center shearing jet-stirred reactor is compared with two traditional jet-stirred reactor designs, the outward cross-injector jet-stirred reactor and the concentric inward and outward jet-stirred reactor. The results show that the present inwardly off-center shearing jet-stirred reactor has significant improvement in terms of mixture uniformity and residence time distribution. Numerical results show the distributions of residence time in the two traditional jet-stirred reactors are wide and long tailed because of the formation of large and stable vortices, and the corresponding mean residence time of the two classical jet-stirred reactors deviates from the theoretical value by about 20%, while the new inwardly off-center shearing jet-stirred reactor has a much narrower residence time distribution and reduces the deviation to 8%, mainly attributed to the smaller vortices generated by an optimized jet arrangement. Moreover, the new inwardly off-center shearing jet-stirred reactor provides a fully optic-accessible platform for kinetic studies of alternative and real jet fuels.